Adverse side-effects of biological agents: Hypersensitivity reactions
نویسندگان
چکیده
منابع مشابه
How to manage hypersensitivity reactions to biological agents?
Biological agents induce cutaneous adverse drug reactions (CADR) different from those observed with xenobiotics. Type alpha is the cytokine release syndrome, type beta are hypersensitivity reactions and type gamma is a cytokine imbalance syndrome. Infusion-reactions, anaphylactoid reactions occur with various biological agents administered intravenously. In non-severe cases the infusion rate ha...
متن کاملHypersensitivity reactions to biological drugs.
Strictly speaking, biological drugs are defined as drugs obtained using biotechnology that act on the immune system. They encompass monoclonal antibodies, fusion proteins, and cytokines. Although they are restricted to specific diseases, they have been increasingly used in recent years, with the consequent reporting of adverse reactions, many of which occur during the postmarketing phase. Becau...
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Sir,—Even though some small changes in heart rate were shown to be statistically significant, no clinical significance was attached to such changes. The study was primarily done to assess the overall need of anticholinergic premedication in patients undergoing minor surgery and as such drugs were not administered on a weight basis. However, Dr Gilmour's comment has aroused our interest in this ...
متن کاملAdverse drug reactions - allergy? side-effect? intolerance?
BACKGROUND Adverse drug reactions (ADRs) vary from life-threatening anaphylaxis to minor common side-effects. OBJECTIVE To provide an overview on the assessment of ADRs. To discuss the features of what may be described as a 'reaction to a drug' in order to highlight those suggestive of allergy, side-effect or intolerance, and what implications this might have for the future use or avoidance o...
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AIM To detect in patients with psoriasis the adverse effects during TNF-a inhibitor therapy. MATERIAL AND METHODS Fifty-seven patients with psoriasis, aged between 12 and 75 years were analyzed. They were treated with different TNF-α antagonists, the maximum treatment duration being 59 months. All patients were followed monthly after the initiation of therapy by clinical checkup, then every 3...
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ژورنال
عنوان ژورنال: Arhiv za farmaciju
سال: 2014
ISSN: 0004-1963
DOI: 10.5937/arhfarm1406457s